Weekly Chest CasesCases by Disease Category

Case No : 1161 Date 2020-01-30

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  • Courtesy of So Hyeon Bak, Heon Han / Kangwon National University Hospital
  • Age/Sex 49 / M
  • Chief ComplaintFever and skin rash
  • Figure 1
  • Figure 2
  • Figure 3
  • Figure 4
  • Figure 5

Diagnosis With Brief Discussion

Diagnosis
Varicella-zoster pneumonia
Radiologic Findings
Fig. 1-5 Axial images of chest CT show randomly distributed, small, ill-defined nodules with a surrounding halo of ground glass opacity in both lungs. The patient showed skin rash. After antiviral therapy, the patients symptoms and lung nodules were considerably improved.
Brief Review
Varicella-zoster virus is a double stranded DNA virus that causes a self-limited benign disease (chickenpox) in children. However, infection of varicella-zoster virus tends to cause serious complications such as varicella-zoster pneumonia in adults with lymphoma and immunocompromised or pregnant patients. The diagnosis of varicella infection is usually based on clinical findings such as skin rash, pulmonary symptoms, and a history of contact with a patient with chickenpox. With recovery from the initial disease, spherical nodules are observed to be scattered randomly throughout the lung parenchyma. Histologically, the nodules are composed of an outer lamellated fibrous capsule that encloses hyalinized collagen or necrotic tissue. Chest CT findings of varicella-zoster pneumonia consist of 1-10 mm well-defined or ill-defined nodules with a surrounding halo of ground glass opacity and coalescence of nodules diffusely throughout both lungs. These finding resolve with the healing of skin lesions after antiviral therapy.
Please refer to
Case 79, Case 328, Case 917, Case 1109,
KSTR Imaging Conference 2003 Summer  Case 2,
References
1. Kim EA et al. Viral pneumonias in adults: radiologic and pathologic findings. Radiographics 2002;22:S137-S149
2. Koo HJ et al. Radiologic and CT features of viral pneumonia. Radiographics 2018;38:719-739
Keywords
lung, Varicella-Zoster pneumonia, Viral infection,

No. of Applicants : 78

▶ Correct Answer : 58/78,  74.4%
  • - DELTA CARE HOSPITAL, THANJAVUR, INDIA , India SIVARAJA SUBRAMANIAM
  • - Hallym University Dongtan Medical Center , Korea (South) MINSU KIM
  • - Chonnam National University Hwasun Hospital , Korea (South) WONGI JEONG
  • - Kyeongpook National University Hospital , Korea (South) HYEONJUN JANG
  • - The Jikei university , Japan TAKU GOMI
  • - The University of Tokyo Hospital , Japan TOSHIHIRO FURUTA
  • - Jiangsu province hospital , China WANGJIAN ZHA
  • - , Korea (South) PARK JONGMIN
  • - NIMS, HYDERABAD , India BHASKAR K
  • - Mayo Clinic , United States AKITOSHI INOUE
  • - university of montreal , Canada Andrei Bogdan Gorgos I
  • - Seoul National University Hospital , Korea (South) SEUNG JIN YOO
  • - radiologist, aditya imaging centre , India VIVEK PATEL
  • - Other , Korea (South) SEONGSU KANG
  • - Diskapi Yildirim Beyazit Hospital, Ankara , Turkey MERIC TUZUN
  • - McGill University Health Center , Canada Alexandre Semionov
  • - Xiamen third hospital , China LI JUN BIAO
  • - Showa University Fujigaoka Hospital , Japan KYOKO NAGAI
  • - Vita Hospital , Brazil DIOGO LAGO PINHEIRO
  • - Cabinet Capricorne, clinique sainte-clotilde , Reunion FABIEN HO
  • - Ondokuz Mayis University , Turkey CETIN CELENK
  • - , Jordan HISHAM IBRAHIM KHATIB
  • - National cancer center hospital east , Japan SHIOTO ODA
  • - National Center for Global Health and Medicine , Japan HIROSHI TAKUMIDA
  • - University of Tsukuba Hospital , Japan SODAI HOSHIAI
  • - chp st martin , France BENOIT HENR MARIOTTE
  • - Hamamatsu University Hospital , Japan HAYATO NOZAWA
  • - , Korea (South) CHOHEE KIM
  • - CH de la Cote Basque , France PAUL ARDILOUZE
  • - Narayana Multispeciality Hospital Jaipur Rajasthan , India JAINENDRA JAIN
  • - Ajou University Hospital , Korea (South) HYERIN KIM
  • - Other , Korea (South) HONG SANG HYUP
  • - Asan Medical Center , Korea (South) JIHOON KIM
  • - , Korea (South) HYEYOUNG CHOI
  • - The University of Tokyo Hospital , Japan RYO KUROKAWA
  • - Ichinomiya Nishi Hospital , Japan Takao Kiguchi
  • - Other , Korea (South) HEE SEOK CHOI
  • - Seoul Veterans Hospital , Korea (South) JANG SEONG WON
  • - TB centre kasaragod. , India rikhy krishnan
  • - Yeungnam University Medical Center , Korea (South) JONGSOO PARK
  • - , Saudi Arabia ALAAELDIN MOHAMED
  • - Ziad Fadhel Moqbel
  • - , Japan YUMI MAEHARA
  • - the first affiliatited hospital of nanjing medical univercity , China HAI XU
  • - Kinki University Faculty of Medicine, , Japan MITSURU MATSUKI
  • - Chungbuk National University Hospital , Korea (South) YOUNGHUN JEON
  • - Asan Medical Center , Korea (South) HYEMIN AHN
  • - University of Tsukuba, Dept of Radiology , Japan MANABU MINAMI
  • - Niigata University , Japan ATSUSHI UEHARA
  • - Gifu University Hospital , Japan Yo Kaneko
  • - Private sector , Greece VASILIOS TZILAS
  • - Hamamatsu University Hospital , Japan YUKI HAYASHI
  • - Toranomon Hospital , Japan KAORU SUMIDA
  • - Nishida Hospital , Japan SHOJI OKUDA
  • - IRSA LA ROCHELLE , France JEAN LUC BIGOT
  • - , Japan KAZUMA TERAUCHI
  • - Chonbuk National University Hospital , Korea (South) KUM JU CHAE
  • - ZIGONG TCM HOSPITAL OF CHINA , China Cao Cunyou
▶ Correct Answer as Differential Diagnosis : 2/78,  2.6%
  • - , Nepal PETER BISTA
  • - Lille , France BENOIST CAPON
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